Enzyme-induced aziridine formation by isolated hepatocytes
| Autor: | Kanya Tonda, Masaharu Hirata, Masamichi Watanabe, Yoshiteru Hata |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Aziridines Biophysics In Vitro Techniques Biochemistry chemistry.chemical_compound Animals Organic chemistry Molecular Biology Reaction conditions chemistry.chemical_classification Inert Glutathione Disulfide Azirines Rats Inbred Strains Cell Biology Metabolism Buffer solution Glutathione Aziridine Rats Enzyme Liver chemistry Reaction system |
| Zdroj: | Biochemical and Biophysical Research Communications. 112:356-360 |
| ISSN: | 0006-291X |
| Popis: | The metabolism of 2-bromoethylaminonaphthoquinone in hepatocytes isolated from rats was studied. This compound was chemically inert in the reaction system used. However, in buffer solution containing isolated hepatocytes, it was gradually converted into aziridinylnaphthoquinone. Under the same reaction conditions, 4-chlorobutylaminonaphthoquinone also gave the cyclization products, pyrrolidinylnaphthoquinone. Cellular GSH decreased in both reactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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