The ruthenium-based nitric oxide scavenger, AMD6221, augments cardiovascular responsiveness to noradrenaline in rats with streptozotocin-induced diabetes
| Autor: | Simon P. Fricker, Dongzhe Song, Simon R. Hutchings, Catherine C.Y. Pang |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Blood Pressure Nitric Oxide Streptozocin Ventricular Function Left Nitric oxide Diabetes Mellitus Experimental chemistry.chemical_compound Norepinephrine Heart Rate Diabetes mellitus Internal medicine medicine Organometallic Compounds Animals Vasoconstrictor Agents Rats Wistar Pharmacology biology business.industry Drug Synergism Free Radical Scavengers Pentetic Acid medicine.disease Streptozotocin Myocardial Contraction Rats Nitric oxide synthase Disease Models Animal Blood pressure Endocrinology chemistry Circulatory system Ventricular pressure biology.protein Vascular Resistance business medicine.drug |
| Zdroj: | European journal of pharmacology. 528(1-3) |
| ISSN: | 0014-2999 |
| Popis: | Excess production of nitric oxide by inducible nitric oxide synthase (iNOS) has been implicated in cardiovascular dysfunction associated with the acute phase of diabetes mellitus. We examined if the selective nitric oxide scavenger, AMD6221 (ruthenium[hydrogen(diethylenetrinitrilo)pentaacetato] chloride) improved cardiovascular function in rats with streptozotocin (60 mg/kg, i.v.)-induced diabetes. The cardiovascular effects of noradrenaline (16.5 nmol/kg/min, i.v.) were measured in thiobutabarbitone-anaesthetised diabetic and control rats before and after acute administration of AMD6221 (80 mg/kg). Rats in the acute phase of diabetes (3 weeks post injection of streptozotocin) had impaired mean arterial pressure, left ventricular systolic pressure and maximum rate of increase (+dP/dt) and decrease (-dP/dt) of left ventricular pressure responses to noradrenaline compared with control rats. AMD6221 significantly augmented noradrenaline-induced increases in left ventricular systolic pressure and +/-dP/dt in the diabetic but not control rats. The results show that selective scavenging of nitric oxide by AMD6221 improved cardiac response to noradrenaline in rats with streptozotocin-induced diabetes. |
| Databáze: | OpenAIRE |
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