The facilitation of tumour growth in the lung by cyclophosphamide in artificial and spontaneous metastases models
| Autor: | L.M. Van Putten, S.J. Cramer, T. Smink, J. de Ruiter |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Time Factors Cyclophosphamide Cell Survival medicine.medical_treatment Mice Inbred Strains Mice Propionibacterium acnes medicine Animals Neoplasm Chemotherapy Lung biology Inoculation Graft Survival Dose fractionation Neoplasms Experimental General Medicine Immunotherapy biology.organism_classification medicine.disease Disease Models Animal medicine.anatomical_structure medicine.drug |
| Zdroj: | European Journal of Cancer (1965). 15:1139-1149 |
| ISSN: | 0014-2964 |
| DOI: | 10.1016/0014-2964(79)90130-0 |
| Popis: | It had been shown previously that treatment of mice with cyclophosphamide before i.v. inoculation of tumour cells enhanced the growth of lung colonies. Results presented here show that treatment with cyclophosphamide after i.v. inoculation of tumour cells could also decrease host resistance against growth of lung colonies. This enhancement could be counteracted by pretreatment with cortisone acetate and is hardly influenced by increasing the tumour load or by dose fractionation of cyclophosphamide. In addition, the increased lung colony formation as found in the artificial model, with i.v. inoculation of tumour cells, was also present in a tumour model in which spontaneous metastases occur. However, the growth promoting effect of cyclophosphamide is for most tumours quantitatively negligible in comparison to the antitumour effect of the drug. |
| Databáze: | OpenAIRE |
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