CD19 regulates ADAM28‐mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells
| Autor: | Beifen Shen, Gencheng Han, Renxi Wang, Gaizhi Zhu, Ning Ma, Xiaoling Liu, Guojiang Chen, He Xiao, Yu Zhang, Chunmei Hou, Yan Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
ADAM28 Lymphoid Tissue Cellular differentiation Antigens CD19 FOXO1 Cleavage (embryo) CD19 03 medical and health sciences Mice 0302 clinical medicine Foxo1 Animals Receptor Notch2 Regulation of gene expression Notch2 Mice Knockout B-Lymphocytes biology Chemistry Forkhead Box Protein O1 MZ B cells Cell Differentiation Cell Biology Original Articles Marginal zone Cell biology Mice Inbred C57BL ADAM Proteins 030104 developmental biology Gene Expression Regulation marginal zone precursors Proteolysis biology.protein Molecular Medicine Original Article Signal transduction 030215 immunology Signal Transduction |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| Popis: | As the first line of defence, marginal zone (MZ) B cells play principal roles in clearing blood‐borne pathogens during infection and are over‐primed in autoimmune diseases. However, the basic mechanisms underlying MZ B‐cell development are still unclear. We found here that CD19 deficiency blocked the differentiation of marginal zone precursors (MZP) to MZ B cells, whereas CD19 expression in CD19‐deficient MZP rescues MZ B‐cell generation. Furthermore, CD19 regulates Notch2 cleavage by up‐regulating ADAM28 expression in MZP. Finally, we found that CD19 suppressed Foxo1 expression to promote ADAM28 expression in MZP. These results suggest that CD19 controls the differentiation of MZP to MZ B cells by regulating ADAM28‐mediated Notch2 cleavage. Thus, we demonstrated the basic mechanisms underlying the differentiation of MZP to MZ B cells. |
| Databáze: | OpenAIRE |
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