Single-nucleotide polymorphism in a local population of Trichophyton rubrum
| Autor: | Kirill A Dmitriev, Ivan M. Pchelin, Galina A. Chilina, Daniil V. Azarov, Natalya V Vasilyeva, Anastasia E. Taraskina |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genotype 030106 microbiology Locus (genetics) Single-nucleotide polymorphism Trichophyton rubrum medicine.disease_cause Polymorphism Single Nucleotide 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Tinea Trichophyton medicine Humans SNP Missense mutation DNA Fungal skin and connective tissue diseases Genetics biology Sequence Analysis DNA General Medicine bacterial infections and mycoses biology.organism_classification Infectious Diseases Genetic Loci Dermatophyte |
| Zdroj: | Medical Mycology. 56:125-128 |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1093/mmy/myx009 |
| Popis: | Trichophyton rubrum is an important causative agent of superficial mycoses worldwide. To uncover a genetic composition of a local population of this fungus, we sequenced A7C99_6411 and A7C99_6714 loci, coding for hypothetical proteins and revealed two complex genotypes, differing by a single missense mutation in each locus. One of the two A7C99_6411/6714 genotypes was not found in tinea pedis cases and demonstrated mostly longer TRS-1 elements when compared to another genotype. Thus, we present a description of nucleotide polymorphism in protein-coding loci in T. rubrum and provide evidence for ecological preferences of T. rubrum genotypes at a local scale. |
| Databáze: | OpenAIRE |
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