Characteristics, complications, and mortality of respiratory syncytial virus compared with influenza infections in hospitalized adult patients in Thailand
| Autor: | Nisa Muangman, Kanyarat Totanarungroj, Run Banlengchit, Kanokwan Rattanasaengloet, Navin Horthongkham, Benjamas Chuaychoo, Niracha Athipanyasilp |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
myalgia Adult Adult hospitalized patients medicine.medical_specialty viruses Infectious and parasitic diseases RC109-216 Respiratory Syncytial Virus Infections Respiratory syncytial virus Virus Internal medicine Influenza Human medicine Humans Respiratory system Respiratory Tract Infections Retrospective Studies Adult patients business.industry Mortality rate virus diseases Retrospective cohort study Seasonality General Medicine respiratory system medicine.disease Thailand Influenza Hospitalization Pneumonia Infectious Diseases Respiratory Syncytial Virus Human medicine.symptom business Complication |
| Zdroj: | International Journal of Infectious Diseases, Vol 110, Iss, Pp 237-246 (2021) |
| ISSN: | 1878-3511 |
| Popis: | Introduction RSV is increasingly recognized in adults. An improved understanding of clinical manifestations and complications may facilitate diagnosis and management. Methods This was a retrospective study of hospitalized patients aged ≥ 18 years with RSV or influenza infection at Siriraj hospital, Thailand between January 2014 and December 2017. Results RSV and/or influenza were detected by RT-PCR in 570 (20.1%) of 2836 patients. After excluding patients coinfected with influenza A and B (n = 5), and with influenza and RSV (n = 3), 141 (5.0%) RSV and 421 (14.8%) influenza patients were analyzed. Over the study period, RSV circulated during the rainy season and peaked in September or October. Patients with RSV were older than patients with influenza and presented significantly less myalgia and fever, but more wheezing. Pneumonia was the most common complication, occurring in 110 (78.0%) of RSV cases and in 295 (70.1%) of influenza cases (p = 0.069). Cardiovascular complications were found in 30 (21.3%) RSV and 96 (22.8%) influenza (p = 0.707), and were reasons for admission in 15 (10.6%) RSV and 50 (11.9%) influenza. The in-hospital mortality rates for RSV (17; 12.1%) and influenza (60; 14.3%) were similar (p = 0.512). Conclusions In Thailand, RSV is a less common cause of adult hospitalization than influenza, but pulmonary and cardiovascular complications, and mortality are similar. Clinical manifestations cannot reliably distinguish between RSV and influenza infection; laboratory-confirmed diagnosis is needed. |
| Databáze: | OpenAIRE |
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