Thee-component, one-pot synthesis of hexahydroazepino[3,4- b ]indole and tetrahydro-1 H -pyrido[3,4- b ]indole derivatives and evaluation of their cytotoxicity
| Autor: | J. S. Yadav, T. Ramalinga Murthy, Shasi V. Kalivendi, B. V. Subba Reddy, M. Vani, A. Venkata Ganesh |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Indoles Pyridines Stereochemistry Clinical Biochemistry One-pot synthesis Pharmaceutical Science Antineoplastic Agents Biochemistry HeLa Structure-Activity Relationship DU145 Cell Line Tumor Drug Discovery Carcinoma medicine Humans Cytotoxicity Molecular Biology Cell Proliferation Indole test Dose-Response Relationship Drug Molecular Structure biology Cytotoxins Chemistry Organic Chemistry Azepines biology.organism_classification medicine.disease MCF-7 Cells Molecular Medicine Ugi reaction Adenocarcinoma Drug Screening Assays Antitumor HeLa Cells |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 24:4501-4503 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2014.07.084 |
| Popis: | A three-component, four-center Ugi reaction has been developed to produce a novel class of 2-aryl-3-oxo-hexahydroazepino[3,4-b]indole and 2-aryl-3-oxo-tetrahydro-1H-pyrido[3,4-b]indole derivatives in good to high yields. A few of them exhibit moderate cytotoxicity against various cancer cell lines such as HeLa (human epithelial cervical cancer), A549 (human lung carcinoma epithelial), DU145 (human prostate carcinoma epithelial) and MCF-7 (human breast adenocarcinoma). |
| Databáze: | OpenAIRE |
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