Morphometric evaluation of traumatic axonal injury and the correlation with post-traumatic cerebral atrophy and functional outcome
| Autor: | Philippe Demaerel, Frederik De Keyzer, Thijs Vande Vyvere, Diana M. Sima, Cedric Bohyn |
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| Rok vydání: | 2023 |
| Předmět: |
Cerebral atrophy
medicine.medical_specialty medicine.diagnostic_test business.industry Traumatic brain injury Computed tomography Diffuse Axonal Injury General Medicine Fluid-attenuated inversion recovery medicine.disease Magnetic Resonance Imaging Brain Injuries Traumatic medicine Image Processing Computer-Assisted Humans Radiology Nuclear Medicine and imaging Neurology (clinical) Radiology Atrophy business |
| Zdroj: | The neuroradiology journal. 35(4) |
| ISSN: | 2385-1996 |
| Popis: | Introduction Imaging plays a crucial role in the diagnosis, prognosis and follow-up of traumatic brain injury. Whereas computed tomography plays a pivotal role in the acute setting, magnetic resonance imaging is best suited to detect the true extent of traumatic brain injury, and more specifically diffuse axonal injury. Post-traumatic brain atrophy is a well-known complication of traumatic brain injury. Purpose This study investigated the correlation between diffuse axonal injury detected with fluid-attenuated inversion recovery and susceptibility-weighted imaging magnetic resonance imaging, post-traumatic brain atrophy and functional outcome (Glasgow outcome scale – extended). Materials and methods Twenty patients with a closed head injury and diffuse axonal injury detected with fluid-attenuated inversion recovery and susceptibility-weighted imaging were included. The total volumes of the diffuse axonal injury fluid-attenuated inversion recovery lesions were determined for each subject’s initial (Results The volumetric fluid-attenuated inversion recovery diffuse axonal injury lesion load showed a significant inverse correlation with functional outcome (Glasgow outcome scale – extended) ( r = −0.57; P = 0.0094) and white matter volume change ( r = −0.50; P = 0.027). In addition, white matter volume change correlated significantly with the Glasgow outcome scale – extended score ( P = 0.0072; r = 0.58). Moreover, there was a strong inverse correlation between longitudinal fluid-attenuated inversion recovery lesion volume change and whole brain volume change ( r = −0.63; P = 0.0028). No significant correlation existed between the number of diffuse axonal injury susceptibility-weighted imaging lesions, brain atrophy and functional outcome. Conclusions Volumetric analysis of diffuse axonal injury on fluid-attenuated inversion recovery imaging and automated brain atrophy calculation are potentially useful tools in the clinical management and follow-up of traumatic brain injury patients with diffuse axonal injury. |
| Databáze: | OpenAIRE |
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