Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage
| Autor: | Sami Tetri, Seppo Juvela, Anna-Maija Lahti, Michaela K. Bode, Juha Huhtakangas |
|---|---|
| Přispěvatelé: | Clinicum, Department of Neurosciences, HUS Neurocenter, Neurokirurgian yksikkö |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Epidemiology Population Symptomatic epilepsy Long-Term 3124 Neurology and psychiatry Cohort Studies 03 medical and health sciences 0302 clinical medicine RISK-FACTOR Risk Factors Internal medicine Post-Stroke epilepsy Medicine Humans Mortality Risk factor PREDICTORS education Stroke Outcome Cerebral Hemorrhage Intracerebral hemorrhage education.field_of_study Epilepsy ILAE business.industry Hazard ratio DEATH 3112 Neurosciences INTERNATIONAL-LEAGUE medicine.disease Confidence interval 3. Good health 030104 developmental biology Neurology Cohort Neurology (clinical) business 030217 neurology & neurosurgery LATE SEIZURES |
| Zdroj: | Epilepsy research. 172 |
| ISSN: | 1872-6844 |
| Popis: | Objectives: This study aimed to determine whether post-stroke epilepsy (PSE) predicts mortality, and to describe the most prominent causes of death (COD) in a long-term follow-up after primary intracerebral hemorrhage (ICH). Methods: We followed 3-month survivors of a population-based cohort of primary ICH patients in Northern Ostrobothnia, Finland, for a median of 8.8 years. Mortality and CODs were compared between those who developed PSE and those who did not. PSE was defined according to the ILAE guidelines. CODs were extracted from death certificates (Statistics Finland). Results: Of 961 patients, 611 survived for 3 months. 409 (66.9%) had died by the end of the follow-up. Pneumonia was the only COD that was significantly more common among the patients with PSE (56% vs. 37% of deaths). In the multivariable models, PSE (hazard ratio [HR] 1.41, 95% confidence interval [CI] 1.06 & ndash;1.87), age (HR 1.07, 95% CI 1.06 & ndash;1.08), male sex (HR 1.35, 95% CI 1.09 & ndash;1.67), dependency at 3 months (HR 1.52, 95% CI 1.24 & ndash;1.88), non-subcortical ICH location (subcortical location HR 0.78, 95% CI 0.61-0.99), diabetes (HR 1.43, 95% CI 1.07 & ndash;1.90) and cancer (HR 1.45, 95% CI 1.06 & ndash;1.98) predicted death in the long-term follow-up. Conclusion: PSE independently predicted higher late morality of ICH in our cohort. Pneumonia-related deaths were more common among the patients with PSE. |
| Databáze: | OpenAIRE |
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