Beneficial effects of lactitol on the composition of gut microbiota in constipated patients
| Autor: | Yu Lan, Xiang Chen Meng, Xu Min Zhang, Le Xu, Jing Nan Li, Xi Wu, Xiao Qing Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Constipation Lactitol Adolescent Gut flora Gastroenterology Feces Young Adult 03 medical and health sciences chemistry.chemical_compound Sugar Alcohols fluids and secretions 0302 clinical medicine RNA Ribosomal 16S Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Aged Bifidobacterium Chronic constipation biology business.industry Middle Aged biology.organism_classification medicine.disease Gastrointestinal Microbiome Bifidobacteriaceae Prebiotics chemistry 030220 oncology & carcinogenesis Chronic Disease Female 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Journal of Digestive Diseases. 21:445-453 |
| ISSN: | 1751-2980 1751-2972 |
| DOI: | 10.1111/1751-2980.12912 |
| Popis: | OBJECTIVE To explore the changes in microbial composition and the corresponding impact after lactitol treatment in constipated patients. METHODS Altogether 29 consecutive outpatients diagnosed with chronic constipation from three centers were recruited and stratified based on their history of diabetes mellitus. All patients were administered with oral lactitol for 2 weeks, and a symptoms diary of constipation was recorded. Fecal samples were collected before and after lactitol treatment, and were analyzed by 16S rRNA sequencing and real-time polymerase chain reaction (PCR) to detect gut microbiota. RESULTS Twenty patients with diabetes mellitus and nine without, all with chronic constipation, were enrolled in this study. After 2-week administration of lactitol, their subscale scores and constipation symptoms significantly decreased (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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