Effects of salmon calcitonin and combination drug therapy on rat adjuvant arthritis
| Autor: | G. R. Bobalik, R. R. Kleszynski, R. A. Zeedyk, Stubbs Rk, J. W. Bastian, J. P. Aldred |
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| Rok vydání: | 1974 |
| Předmět: |
Calcitonin
Male medicine.medical_specialty Hydrocortisone Bone density Immunology Arthritis Hindlimb Toxicology Mycobacterium Salmon Internal medicine medicine Phenylbutazone Animals Pharmacology (medical) Tibia Pharmacology business.industry medicine.disease Rheumatology Rats Radiography Endocrinology Drug Therapy Combination business medicine.drug |
| Zdroj: | Agents and Actions. 4:364-369 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01964938 |
| Popis: | The effect of chronic administration of salmon calcitonin (SCT) to rats with adjuvant arthritis was studied. Compared to arthritic controls, 10 units/kg day in a divided dose of SCT given s.c. resulted in a significant inhibition of paw edema and a reduction in the marked deterioration of the bones of the hind limbs, particularly those of the tarsus, as visualized by x-ray. In addition, a pronounced increase in bone density in the proximal metaphyseal area of the tibia was consistently observed in calcitonin treated animals. Animals treated with SCT also showed improved clinical symptoms including increased mobility and decreased sensitivity to handling compared to arthritic controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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