Generation of mutagenicity by ozonation of humic substances' components
| Autor: | Mitsunobu Hibino, Youki Ose, Takahiko Sato, Hiroaki Matsuda, Hideaki Kito, Hisamitsu Nagase |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Salmonella typhimurium
endocrine system Environmental Engineering Ethyl acetate Syringaldehyde Ames test Gel permeation chromatography chemistry.chemical_compound Ozone Vanillic acid Animals Environmental Chemistry Organic chemistry Waste Management and Disposal Biotransformation Humic Substances Dichloromethane Vanillic Acid Chromatography Mutagenicity Tests Vanillin fungi food and beverages Pollution Dibutyl Phthalate chemistry Sephadex Benzaldehydes Microsomes Liver Mutagens |
| Zdroj: | The Science of The Total Environment. 116:1-13 |
| ISSN: | 0048-9697 |
| Popis: | Components of humic substances, such as vanillin, syringaldehyde, vanillic acid and di- n -butylphtalate, were ozonated and subjected to the mutagenicity assay using Salmonella typhimurium TA 98 and 100 with and without S9 mix. The strong mutagenic activity was found on all components except di- n -butylphtalate by strain TA 100 with and without S9 mix. Substances with strong mutagenic activity in ozonated vanillin were water-soluble and were slightly extracted with benzene, dichloromethane and ethyl acetate. Following gel chromatography on Sephadex G-10, the strong mutagens generated by ozonation were found with molecular weights > 300. |
| Databáze: | OpenAIRE |
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