Capicua regulates the development of adult-born neurons in the hippocampus
| Autor: | Saloni Sharma, Qiumin Tan, Spencer D. Balay, Graydon Yee, Brenna Hourigan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cell biology
Molecular biology Science Neurogenesis Hippocampus Dendrite Hippocampal formation Biology Article 03 medical and health sciences Mice 0302 clinical medicine Neural Stem Cells Precursor cell Developmental biology medicine Animals Progenitor cell 030304 developmental biology Mice Knockout 0303 health sciences Multidisciplinary Dentate gyrus Pyramidal Cells Cell Differentiation Neural stem cell Repressor Proteins medicine.anatomical_structure nervous system Dentate Gyrus Medicine Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2045-2322 |
| Popis: | New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation. To generate functional adult-born neurons, neural progenitor cells proliferate to expand the precursor cell pool and differentiate into neurons. Newly generated cells then undergo postmitotic maturation to migrate to their final destination and develop elaborate dendritic branching, which allows them to receive input signals. Little is known about factors that regulate neuronal differentiation, migration, and dendrite maturation during adult hippocampal neurogenesis. Here, we show that the transcriptional repressor protein capicua (CIC) exhibits dynamic expression in the adult dentate gyrus. Conditional deletion of Cic from the mouse dentate gyrus compromises the adult neural progenitor cell pool without altering their proliferative potential. We further demonstrate that the loss of Cic impedes neuronal lineage development and disrupts dendritic arborization and migration of adult-born neurons. Our study uncovers a previously unrecognized role of CIC in neurogenesis of the adult dentate gyrus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|