The peculiarities of cancer cell metabolism: A route to metastasization and a target for therapy
| Autor: | Henrique J. Cardoso, Sílvia Socorro, Marília I. Figueira, Cátia V. Vaz, Tiago Ma. Carvalho |
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| Rok vydání: | 2019 |
| Předmět: |
Metabolic reprogramming
Cancer therapy Antineoplastic Agents 01 natural sciences Metastasis Structure-Activity Relationship 03 medical and health sciences Neoplasms Drug Discovery Tumor Microenvironment medicine Humans Glycolysis 030304 developmental biology Pharmacology 0303 health sciences Glutaminolysis Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Cancer General Medicine Metabolism medicine.disease 0104 chemical sciences Cancer cell Cancer research |
| Zdroj: | European Journal of Medicinal Chemistry. 171:343-363 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2019.03.053 |
| Popis: | The last decade has witnessed the peculiarities of metabolic reprogramming in tumour onset and progression, and their relevance in cancer therapy. Also, it has been indicated that the metastatic process may depend on the metabolic rewiring and adaptation of cancer cells to the pressure of tumour microenvironment and limiting nutrient availability. The present review gatherers the existent knowledge on the influence of tumour microenvironment and metabolic routes driving metastasis. A focus will be given to glycolysis, fatty acid metabolism, glutaminolysis, and amino acid handling. In addition, the role of metabolic waste driving metastasization will be explored. Finally, we discuss the status of cancer treatment approaches targeting metabolism. This knowledge revision will highlight the critical metabolic targets in metastasis and the chemicals already used in preclinical studies and clinical trials, providing clues that would be further exploited in medicinal chemistry research. |
| Databáze: | OpenAIRE |
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