Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS
| Autor: | Robin L. Gal, D. T. Long, J. Garovoy, Pamela S. Moke, Roy W. Beck, Stephen R. Cole, Kevin E. Kip, Robin R. Lincoln, Stephen L. Hauser, Jorge R. Oksenberg |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Hla haplotypes business.industry Multiple sclerosis Eye disease Odds ratio Human leukocyte antigen medicine.disease Gastroenterology Confidence interval Central nervous system disease Ophthalmology Internal medicine Optic nerve medicine Brain mri Abnormal brain MRI Cranial nerve disease Optic neuritis Neurology (clinical) medicine.symptom Allele business |
| Zdroj: | American Journal of Ophthalmology. 130:690-691 |
| ISSN: | 0002-9394 |
| Popis: | Article abstract The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p = 0.04). The association was most apparent among patients with signal abnormalities on baseline brain MRI. |
| Databáze: | OpenAIRE |
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