Postmortem Distribution of Tapentadol and N-Desmethyltapentadol
| Autor: | Scott J. Larson, Ciena Bayard, Joseph Pestaner, Sunil K. Prashar, Marie Pierre-Louis, Lucas W. Zarwell |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Health Toxicology and Mutagenesis Receptors Opioid mu Pharmacology Toxicology Analytical Chemistry Young Adult Phenols medicine Humans Environmental Chemistry Neurotransmitter Uptake Inhibitors Tissue Distribution Tetrahydrocannabinol Phencyclidine Biotransformation Pantoprazole Chemical Health and Safety Chemistry Selected reaction monitoring Middle Aged Methamphetamine Tapentadol Analgesics Opioid Liver Female Diazepam medicine.drug Methadone |
| Zdroj: | Journal of Analytical Toxicology. 36:440-443 |
| ISSN: | 1945-2403 0146-4760 |
| DOI: | 10.1093/jat/bks041 |
| Popis: | The following tests were completed for the detection of drugs in the subject’s femoral blood: volatiles, immunoassay [Orasure, Bethlehem, PA: amphetamines, barbiturates, benzodiazepines, cocaine, methadone, phencyclidine (PCP), opiates, methamphetamine, tetrahydrocannabinol (THC)], full scan gas chromatography– mass spectrometry with nitrogen phosphorus detection (GC –MS-NPD) base screen, and liquid chromatography–tandem mass spectrometry (LC – MS-MS) directed multiple reaction monitoring (MRM) screen (180 drugs). The immunoassay produced a positive benzodiazepine response, which was confirmed in both the base screen and with GC – MS quantitation. An unknown peak with no library match was also found in the base screen (m/z 58, 221, 107). Upon receiving these preliminary results and following discussions with the medical examiner, further interviews with the family revealed that the decedent “sometimes took a pill to energize self” from an unmarked pill bottle. Using collegial assistance it was determined that this peak was may be the compound tapentadol. The decedent had no pharmaceutical prescriptions for tapentadol or diazepam, but over the course of the previous month had received prescriptions for enoxaparin, albuterol, ipratropium, petrolat, ceftriaxone, pantoprazole, furosemide, gentamicin, advair, senna and Colace. Our laboratory would not expect to detect any of these drugs at therapeutic concentrations, with the exception of albuterol. None of these were detected. Tapentadol was confirmed by LC–MS-MS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|