New perfluoroalkylated amphiphilic methacrylates bearing sulfinyl group as monomers for biomedical applications: water content and oxygen permeability of their copolymers with DEGMA
Autor: | Martin Přádný, Jana Wichterlová, Jan Duchek, Robert Kaplánek, Jiří Michálek, Oldřich Paleta, Dana Chmelíková, Vladimír Církva |
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Rok vydání: | 2005 |
Předmět: |
Pharmacology
Fluorocarbons Magnetic Resonance Spectroscopy Surface Properties Organic Chemistry Diethylene glycol chemistry.chemical_element Biocompatible Materials General Medicine Methacrylate Oxygen Gas Chromatography-Mass Spectrometry Permeability chemistry.chemical_compound Oxygen permeability Refractometry Monomer chemistry Sulfanyl Drug Discovery Amphiphile Polymer chemistry Copolymer Methacrylates |
Zdroj: | European journal of medicinal chemistry. 41(11) |
ISSN: | 0223-5234 |
Popis: | Perfluoroalkylated methacrylates 7a – c bearing sulfinyl group within a straight-chain ester group, i.e. CH 2 =C(CH 3 )CO 2 CH 2 CH 2 S(O)–CH 2 CH 2 CF 2 (CF 2 CF 2 ) n CF 3 ( n = 1–3) were prepared by two alternative synthetic sequences from 2-[(polyfluoroalkyl)sulfanyl]ethanols HOCH 2 CH 2 SCH 2 CH 2 CF 2 (CF 2 CF 2 ) n CF 3 ( n = 1–3) in overall yields of 88–91%. Copolymers of 7a – c with diethylene glycol methacrylate (DEGMA) prepared in bulk under radical conditions display high transparency, increased water content and good oxygen permeability properties, which are advantageous for their application in ophthalmology and as prosthetic materials. |
Databáze: | OpenAIRE |
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