Accelerated long‐term forgetting over three months in asymptomatic APOE ɛ4 carriers
| Autor: | Pablo Martinez-Lage, Juan Fortea, Natalia Valech, Jaume Olives, Matti Laine, Lorena Rami, María León, Adrià Tort-Merino, Raquel Sánchez-Valle, Mirian Ecay-Torres, Antoni Rodríguez-Fornells, Ainara Estanga |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Heterozygote medicine.medical_specialty Time Factors Neurosciences. Biological psychiatry. Neuropsychiatry tau Proteins Disease Brief Communication Gastroenterology Asymptomatic 03 medical and health sciences Apolipoproteins E Tau Proteins 0302 clinical medicine Cerebrospinal fluid Alzheimer Disease Internal medicine medicine Humans Cognitive Dysfunction RC346-429 Aged Amyloid beta-Peptides Forgetting business.industry General Neuroscience digestive oral and skin physiology Middle Aged Peptide Fragments Pathophysiology 030104 developmental biology Dementia Female Neurology. Diseases of the nervous system Neurology (clinical) medicine.symptom Brief Communications business Biomarkers 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 477-484 (2021) |
| ISSN: | 2328-9503 |
| DOI: | 10.1002/acn3.51245 |
| Popis: | Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Agencia Estatal de Investigación (AEI). Accelerated long-term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer's disease (AD) biomarkers. We examined ALF in APOE ɛ4 carriers versus noncarriers, and its relationships with AD cerebrospinal fluid (CSF) biomarkers. We found ALF over three months in APOE ɛ4 carriers (F(1,19) = 5.60; P < 0.05; Cohen's d = 1.08), and this performance was associated with abnormal levels of the CSF Aβ/ptau ratio (r = −.614; P < 0.01). Our findings indicate that ALF is detectable in at-risk individuals, and that there is a relationship between ALF and the pathophysiological processes underlying AD. |
| Databáze: | OpenAIRE |
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