Inhaled Hydrogen Sulfide Prevents Endotoxin-Induced Systemic Inflammation and Improves Survival by Altering Sulfide Metabolism in Mice
| Autor: | Kentaro Tokuda, Kotaro Kida, Ashok Khatri, Fumito Ichinose, Hideo Kimura, Ettore Crimi, Eizo Marutani, Masahiko Bougaki |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Lipopolysaccharide Sulfide Physiology Clinical Biochemistry Anti-Inflammatory Agents Inflammation Sulfides Systemic inflammation Biochemistry Proinflammatory cytokine Mice chemistry.chemical_compound Internal medicine Administration Inhalation medicine Animals Hydrogen Sulfide Molecular Biology General Environmental Science chemistry.chemical_classification Mice Inbred BALB C Lung biology Interleukin Cell Biology equipment and supplies Endotoxins Forum Original Research CommunicationsHydrogen Sulfide (H. Kimura Ed.) Endocrinology medicine.anatomical_structure chemistry Myeloperoxidase Immunology biology.protein General Earth and Planetary Sciences medicine.symptom |
| Zdroj: | Antioxidants & Redox Signaling. 17:11-21 |
| ISSN: | 1557-7716 1523-0864 |
| DOI: | 10.1089/ars.2011.4363 |
| Popis: | Aims: The role of hydrogen sulfide (H2S) in endotoxin (lipopolysaccharide [LPS])-induced inflammation is incompletely understood. We examined the impact of H2S breathing on LPS-induced changes in sulfide metabolism, systemic inflammation, and survival in mice. Results: Mice that breathed air alone exhibited decreased plasma sulfide levels and poor survival rate at 72 h after LPS challenge. Endotoxemia markedly increased alanine aminotransferase (ALT) activity and nitrite/nitrate (NOx) levels in plasma and lung myeloperoxidase (MPO) activity in mice that breathed air. In contrast, breathing air supplemented with 80 ppm of H2S for 6 h after LPS challenge markedly improved survival rate compared to mice that breathed air alone (p |
| Databáze: | OpenAIRE |
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