Proapoptotic, Anti-Cell Proliferative, Anti-Inflammatory And Antiangiogenic Potential Of Carnosic Acid During 7,12 Dimethylbenz[A]Anthracene-Induced Hamster Buccal Pouch Carcinogenesis

Autor: Simon Silvan, Nagarethinam Baskaran, Shanmugam Manoharan, Krishnamoorthy Vasudevan, Duraisamy Palanimuthu, Duraisamy Rajasekaran
Rok vydání: 2012
Předmět:
Male
Vascular Endothelial Growth Factor A
Pathology
medicine.medical_specialty
Carcinogenesis
9
10-Dimethyl-1
2-benzanthracene
Liquid paraffin
Anti-Inflammatory Agents
DMBA
Angiogenesis Inhibitors
Apoptosis
chemistry.chemical_compound
Proliferating Cell Nuclear Antigen
oral cancer
apoptosis
angiogenesis
inflammation
cell proliferation
Drug Discovery
medicine
Animals
Anticarcinogenic Agents
Cyclin D1
Cell Proliferation
Mouth neoplasm
Mesocricetus
biology
Plant Extracts
7
12-Dimethylbenz[a]anthracene
Carnosic acid
biology.organism_classification
Antineoplastic Agents
Phytogenic
Research Papers
Rosmarinus
Proliferating cell nuclear antigen
stomatognathic diseases
Vascular endothelial growth factor A
Complementary and alternative medicine
chemistry
Abietanes
Carcinoma
Squamous Cell
biology.protein
Cancer research
Mouth Neoplasms
Inflammation Mediators
Proto-Oncogene Proteins c-fos
Biomarkers
Phytotherapy
Zdroj: African Journal of Traditional, Complementary and Alternative Medicines; Vol 10, No 1 (2013); 102-112
ISSN: 0189-6016
DOI: 10.4314/ajtcam.v10i1.14
Popis: The present study has investigated the modulating effect of carnosic acid on the expression pattern of cell proliferative (proliferating cell nuclear antigen (PCNA) cyclin D1 and a transcription factor c-fos), apoptotic (p53, Bcl-2, Bax caspase -3 and 9), inflammatory (Nuclear factor kappa B (NFκB) and cyclooxygenase-2 (COX- 2) and angiogenic (vascular endothelial growth factor (VEGF) markers during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors were developed in the hamsters buccal pouches by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Hundred per cent tumour formation (well-differentiated squamous cell carcinoma) accompanied by deregulation in the above mentioned molecular markers was noticed in hamsters treated with DMBA alone (tumour bearing hamsters). Oral administration of carnosic acid at dose of 10mg/kg bw to hamsters treated with DMBA not only completely prevented the tumour formation, but also corrected the abnormalities in the expression pattern of molecular markers. The present study suggests that carnosic acid might have inhibited the tumour formation by exerting anti-cell-proliferative, anti-inflammatory, anti-angiogenic and apoptotic potential during DMBA-induced hamster buccal pouch carcinogenesis.
Databáze: OpenAIRE
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