Regional distribution of 14C-zonisamide in rat brain
| Autor: | Hisaki Tanoue, Takashi Mimaki, Hisashi Miyazaki, Makoto Mino, Yoshimasa Matsunaga |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum Thalamus Central nervous system Midbrain Internal medicine Cortex (anatomy) medicine Animals Rats Wistar Medulla Chemistry Brain Isoxazoles Rats medicine.anatomical_structure Endocrinology nervous system Neurology Zonisamide Cerebral cortex Injections Intravenous Autoradiography Anticonvulsants Neurology (clinical) Primary motor cortex Neuroscience |
| Zdroj: | Epilepsy Research. 17:233-236 |
| ISSN: | 0920-1211 |
| DOI: | 10.1016/0920-1211(94)90053-1 |
| Popis: | Zonisamide (1,2-benzisoxazole-3-methane sulfonamide) is a new antiepileptic drug developed in Japan. This compound was proven to possess a strong inhibitory effect on convulsions of cortical origin, whether induced by electric or chemical stimuli. Regional distribution of 14C-zonisamide was investigated in rat brain using autoradiography. A high uptake of 14C activity was observed in the cerebral cortex and the midbrain. A pair-match analysis of primary motor cortex versus primary sensory cortex revealed a slightly higher uptake in primary motor cortex. In the cerebellum, a higher uptake was observed in the cortex than medulla. Sagittal section analyses revealed that a high uptake of 14C activity was observed in the cerebral cortex and colliculus, and a moderate uptake was seen in the cerebellum, thalamus, hypothalamus, and striatal body, thus suggesting the distribution of 14C-zonisamide is similar to that of flunitrazepam and phenytoin. |
| Databáze: | OpenAIRE |
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