Effect of oral N-acetylcysteine administration on human blood neutrophil and monocyte function
| Autor: | Gerd Stafanger, Niels Høiby, Christian Koch, Tim Kåre Jensen, Arsalan Kharazmi, Henrik Nielsen, Svend Stenvang Pedersen, Peter Oluf Schiøtz |
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| Rok vydání: | 1988 |
| Předmět: |
Microbiology (medical)
Neutrophils Administration Oral Pharmacology Cystic fibrosis Monocytes Pathology and Forensic Medicine Acetylcysteine chemistry.chemical_compound medicine Immunology and Allergy Humans Opsonin Monocyte Zymosan Proteolytic enzymes Chemotaxis General Medicine medicine.disease In vitro Chemotaxis Leukocyte medicine.anatomical_structure chemistry Immunology Luminescent Measurements medicine.drug |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 96(1) |
| ISSN: | 0903-4641 |
| Popis: | N-acetylcysteine (NAC) is known to be a scavenger of free oxygen radicals, and recent in vitro studies have demonstrated that it is also able to inhibit leukocyte function. The clinical significance of these effects is, however, not known. In this study we have measured the effect on human blood neutrophil and monocyte function of a single 400 mg dose of NAC administered orally. Administration of NAC to ten healthy volunteers resulted in significant reduction of neutrophil chemiluminescence response following activation by opsonized zymosan as compared to four non-treated persons acting as controls. No effect was observed on the chemotaxis of either cell type or on monocyte chemiluminescence response. These findings suggest that NAC may be beneficial in clinical conditions like cystic fibrosis, where tissue damage may be a consequence of the effects of increased release of toxic oxygen radicals and proteolytic enzymes. |
| Databáze: | OpenAIRE |
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