Anticomplementary activity of stilbenes from medicinal plants

Autor:	Jung Joon Lee, Si Hyung Park, Sei-Ryang Oh, Hyeong-Kyu Lee, Im Seon Lee, Kyung Seop An, Keun Young Jung, Shi Yong Ryu
Rok vydání:	1998
Předmět:	Complement Inactivator Proteins Plants Medicinal Traditional medicine Stereochemistry Organic Chemistry Methylation In Vitro Techniques Resveratrol In vitro Oxyresveratrol chemistry.chemical_compound chemistry Stilbenes Drug Discovery Molecular Medicine Rhaponticin Medicinal plants IC50 Piceid
Zdroj:	Archives of Pharmacal Research. 21:703-706
ISSN:	1976-3786 0253-6269
DOI:	10.1007/bf02976761
Popis:	The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4'-methoxystilbene (3) was most potent with IC50 value of 1.5 x 10(-4) M followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4',5-tetrahydroxystilbene-2-O-beta-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4' of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2' of 1 or C-3' of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.
Databáze:	OpenAIRE
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