Study of the Mechanical Behavior of Subcellular Organelles Using a 3D Finite Element Model of the Tensegrity Structure
| Autor: | Arkady Voloshin, Gholamreza Mohammadi Khunsaraki, Hanieh Niroomand Oscuii |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
0206 medical engineering 02 engineering and technology lcsh:Technology lcsh:Chemistry cell mechanics Tensegrity Organelle General Materials Science subcellular organelles Cytoskeleton Instrumentation lcsh:QH301-705.5 Fluid Flow and Transfer Processes Atomic force microscopy lcsh:T Process Chemistry and Technology General Engineering 021001 nanoscience & nanotechnology 020601 biomedical engineering Finite element method lcsh:QC1-999 Computer Science Applications Membrane Reaction lcsh:Biology (General) lcsh:QD1-999 Cytoplasm lcsh:TA1-2040 Biophysics tensegrity 0210 nano-technology lcsh:Engineering (General). Civil engineering (General) lcsh:Physics cell structure |
| Zdroj: | Applied Sciences, Vol 11, Iss 249, p 249 (2021) Applied Sciences Volume 11 Issue 1 |
| ISSN: | 2076-3417 |
| Popis: | A tensegrity model can be used to describe the mechanical behavior of living cells. A finite element model (FEM) was used to assess the mechanical contribution of subcellular organelles. Continuum parts like the cytoplasm and membrane were modeled as continuous elements, while the tensegrity was chosen to model the cytoskeleton and nucleoskeleton. An atomic force microscope load was implemented to simulate the external load. The cell components were loaded separately to evaluate their mechanical contributions. The analysis started with a single cytoplasm and each of the cell components was added in consecutive steps. The results showed that the cytoskeleton carried the largest part of the reaction force. The cytoplasm was the second important component of the cell&rsquo s mechanical response. It was shown that the nucleoskeleton has a stiffer structure than the membrane and cytoplasm. The cytoskeleton supported approximately 90% of the reaction force, while the cytoplasm carried 9% and the shell parts and nucleoskeleton were responsible for about 1%. |
| Databáze: | OpenAIRE |
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