In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum
| Autor: | Robert Farinotti, J. Le Bras, C. Gillotin, François Gimenez, L. K. Basco |
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| Rok vydání: | 1992 |
| Předmět: |
ENPIROLINE
Pyridines Plasmodium falciparum Pharmacology chemistry.chemical_compound Antimalarials Halofantrine parasitic diseases medicine Animals Pharmacology (medical) biology Dose-Response Relationship Drug Mefloquine Stereoisomerism Drug susceptibility Phenanthrenes biology.organism_classification In vitro chemistry Enantiomer medicine.drug Research Article |
| Zdroj: | British journal of clinical pharmacology. 33(5) |
| ISSN: | 0306-5251 |
| Popis: | The in vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline was compared against chloroquine-resistant and -susceptible strains of Plasmodium falciparum using a semi-micro drug susceptibility test. For each strain, the corresponding enantiomers exhibited similar activities. The enantiomers of halofantrine were the most active against both susceptible and resistant strains, followed by the enantiomers of mefloquine and enpiroline. |
| Databáze: | OpenAIRE |
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