Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging
| Autor: | Jürgen Hennig, Jan-Bernd Hövener, Philipp Rovedo, W. Schimpf, Christoph W. Müller, Stephan Knecht, T. Lickert, D. von Elverfeldt, Jason G. Skinner, A. Dost, Andreas B. Schmidt, Niels Schwaderlapp, Stephan Berner |
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| Přispěvatelé: | Publica |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Thermodynamic equilibrium Science Physics::Medical Physics General Physics and Astronomy Contrast Media 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology Article law.invention Nuclear magnetic resonance Liquid state law medicine Animals Humans Hyperpolarization (physics) Carbon Isotopes Multidisciplinary medicine.diagnostic_test Staining and Labeling 010405 organic chemistry Carbon-13 Water Magnetic resonance imaging General Chemistry Polarizer Polarization (waves) Magnetic Resonance Imaging 0104 chemical sciences Rats Magnetic Fields Magnet Hydrogenation Propionates Hydrogen |
| Zdroj: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
| ISSN: | 2041-1723 |
| Popis: | Hyperpolarized (HP) tracers dramatically increase the sensitivity of magnetic resonance imaging (MRI) to monitor metabolism non-invasively and in vivo. Their production, however, requires an extra polarizing device (polarizer) whose complexity, operation and cost can exceed that of an MRI system itself. Furthermore, the lifetime of HP tracers is short and some of the enhancement is lost during transfer to the application site. Here, we present the production of HP tracers in water without an external polarizer: by Synthesis Amid the Magnet Bore, A Dramatically Enhanced Nuclear Alignment (SAMBADENA) is achieved within seconds, corresponding to a hyperpolarization of ∼20%. As transfer of the tracer is no longer required, SAMBADENA may permit a higher polarization at the time of detection at a fraction of the cost and complexity of external polarizers. This development is particularly promising in light of the recently extended portfolio of biomedically relevant para-hydrogen-tracers and may lead to new diagnostic applications. Hyperpolarized MRI uses molecules with a nuclear spin polarization beyond the thermodynamic equilibrium to enhance imaging contrast. Here, Schmidt et al. enable a single MRI system to both generate a hyperpolarized tracer and perform imaging, eliminating the need for an external polarizer. |
| Databáze: | OpenAIRE |
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