Chondrosarcoma of the Osseous Spine Treated by Surgery With or Without Radiotherapy
| Autor: | Chen Chunhui, Yan Lin, Kevin Phan, Wu Aimin, Yan Michael Li, Li-Lian Zhang, Jing-Wei Zheng, Ralph J. Mobbs, Wen-Fei Ni, Dong Chen, Lin Zhongke, Xiang-Yang Wang |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Adolescent medicine.medical_treatment Chondrosarcoma Kaplan-Meier Estimate Young Adult 03 medical and health sciences 0302 clinical medicine Epidemiology medicine Humans Combined Modality Therapy Orthopedics and Sports Medicine Longitudinal Studies Young adult Stage (cooking) Child Propensity Score Aged Chemotherapy Spinal Neoplasms business.industry Infant Middle Aged musculoskeletal system medicine.disease Surgery Radiation therapy Child Preschool 030220 oncology & carcinogenesis Propensity score matching Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Spine Surgery: A Spine Publication. 31:E310-E316 |
| ISSN: | 2380-0186 |
| DOI: | 10.1097/bsd.0000000000000666 |
| Popis: | STUDY DESIGN This was a longitudinal cohort study. OBJECTIVE The main objective of this study was to investigate the outcomes of surgery with or without radiotherapy during treatment of patients with chondrosarcoma of the osseous spine. SUMMARY OF BACKGROUND DATA Chondrosarcoma is a primary spinal malignant tumor; chemotherapy and radiotherapy (RT) are generally unsuccessful, and thus, the main treatment of choice is complete en bloc resection. However, even with complete resection, these patients still have a significant rate of recurrence, morbidity, and mortality. Although there have been reports that the addition of RT to surgery may lead to increased survival and better cancer control, the evidence of the efficacy of RT remains controversial. MATERIALS AND METHODS Patients diagnosed with chondrosarcoma who are then treated by surgery alone or surgery+RT were identified and extracted from the SEER (Surveillance, Epidemiology, and End Results) database (1973-2013). Propensity score matched (PSM) analysis was performed to balance patient characteristics between surgery alone and surgery+RT groups. Patients with a different grade and stage were stratified and analyzed. RESULTS A total of 778 patients with chondrosarcoma of the osseous spine treated by surgery alone or surgery+RT were extracted from the SEER database. Before PSM, the unadjusted Kaplan-Meier curve and bivariable Cox proportional hazard regression models showed that the surgery alone group had higher chondrosarcoma cancer-specific survival and overall survival than the surgery+RT group (both P |
| Databáze: | OpenAIRE |
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