Passive Smoking Increases the Risk for Intestinal Surgeries in Patients With Crohn’s Disease
| Autor: | Pavol Papay, Wolfgang Miehsler, Harald Vogelsang, Walter Reinisch, Donata Lissner, Gottfried Novacek, Sieglinde Reinisch, Christian Primas, Clemens Dejaco, Susanna Scharrer |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Crohn's disease Passive smoking Proportional hazards model business.industry Hazard ratio Gastroenterology Odds ratio Disease medicine.disease medicine.disease_cause Crohn Disease Risk Factors Internal medicine Cohort medicine Humans Immunology and Allergy Tobacco Smoke Pollution Risk factor business Digestive System Surgical Procedures |
| Zdroj: | Inflammatory Bowel Diseases. 27:379-385 |
| ISSN: | 1536-4844 1078-0998 |
| Popis: | Background Despite substantial evidence on the negative effect of active smoking, the impact of passive smoking on the course of Crohn’s disease (CD) remains largely unclear. Our aim was to assess passive smoking as a risk factor for intestinal surgeries in CD. Methods The study was conducted in a university-based, monocentric cohort of 563 patients with CD. Patients underwent a structured interview on exposure to passive and active smoking. For clinical data, chart review was performed. Response rate was 84%, leaving 471 cases available for analysis. For evaluation of the primary objective, which was the impact of exposure to passive smoking on the risk for intestinal surgery, only never actively smoking patients were included. Results Of 169 patients who never smoked actively, 91 patients (54%) were exposed to passive smoking. Exposed patients were more likely to undergo intestinal surgery than nonexposed patients (67% vs 30%; P < 0.001). Multivariate Cox regression analysis revealed that passive smoking was an independent risk factor for intestinal surgeries (hazard ratio, 1.7; 95% CI, 1.04–2.9; P = 0.034) after adjustment for ileal disease at diagnosis (hazard ratio, 2.9; 95% CI, 1.9–4.5; P < 0.001) and stricturing or penetrating behavior at diagnosis (hazard ratio, 1.9; 95% CI, 1.2–3.1; P = 0.01). Passive smoking during childhood was a risk factor for becoming an active smoker in later life (odds ratio, 2.2; 95% CI, 1.5–3.2; P < 0.001). Conclusion Passive smoking increases the risk for intestinal surgeries in patients with CD. |
| Databáze: | OpenAIRE |
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