Design and evaluation of a chronic EMG multichannel detection system for long-term recordings of hindlimb muscles in behaving mice
| Autor: | Matthew C. Tresch, Vicki M. Tysseling, Rebecca Imhoff, Brad Lookabaugh, Lindsay E. Janes, Charles J. Heckman, Katharina A. Quinlan, Shyma Ramalingam |
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| Rok vydání: | 2012 |
| Předmět: |
Biophysics
Neuroscience (miscellaneous) Mice Transgenic Hindlimb Electromyography Behavioral or Article Mice Superoxide Dismutase-1 Physical Conditioning Animal medicine Animals Point Mutation Amyotrophic lateral sclerosis Muscle Skeletal Spinal cord injury Spinal Cord Injuries Physical conditioning medicine.diagnostic_test Extramural business.industry Superoxide Dismutase Disease progression Amyotrophic Lateral Sclerosis Equipment Design medicine.disease Electrodes Implanted Disease Models Animal Disease Progression Neurology (clinical) business Neuroscience Locomotion |
| Zdroj: | Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. 23(3) |
| ISSN: | 1873-5711 |
| Popis: | Mouse models are commonly used for identifying the behavioral consequences of genetic modifications, progression or recovery from disease or trauma models, and understanding spinal circuitry. Electromyographic recordings (EMGs) are recognized as providing information not possible from standard behavioral analyses involving gross behavioral or kinematic assessments. We describe here a method for recording from relatively large numbers of muscles in behaving mice. We demonstrate the use of this approach for recording from hindlimb muscles bilaterally in intact animals, following spinal cord injury, and during the progression of ALS. This design can be used in a variety of applications in order to characterize the coordination strategies of mice in health and disease. |
| Databáze: | OpenAIRE |
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