Response to treatment in women with chronic myeloid leukemia during pregnancy and after delivery
| Autor: | Kateřina Machová Poláková, Marketa Markova, Petr Cetkovský, Hana Klamova, Magda Siskova, Jana Moravcová |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Dasatinib Antineoplastic Agents 3rd trimester Piperazines Pregnancy Interferon Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Internal medicine medicine Humans Leukapheresis neoplasms business.industry Myeloid leukemia Imatinib Hematology Delivery Obstetric medicine.disease Response to treatment Thiazoles Pyrimidines Benzamides Immunology Imatinib Mesylate Female Interferons business Pregnancy Complications Neoplastic medicine.drug |
| Zdroj: | Leukemia Research. 33:1567-1569 |
| ISSN: | 0145-2126 |
| Popis: | Here we report response to treatment of chronic myeloid leukemia (CML) of five pregnant women during and after pregnancy. CML was diagnosed during pregnancy in three patients. Pregnancy was confirmed during CML in two patients: in one in the 21st week of pregnancy while on imatinib, in another in the 12th week during the interferon treatment. Interferon with leukapheresis when needed was applied in the 2nd and 3rd trimester. All patients except one achieved complete hematological response during pregnancy. After delivery four patients achieved partial cytogenetic response on imatinib and two patients achieved major molecular response after crossover to dasatinib. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect