Apoptosis in peripheral blood lymphocytes in intestinal tuberculosis and Crohn's disease: Implications to diagnostic differentiation
| Autor: | Mamatha Vishwanatha Shetty, Kanive Parashiva Guruprasad, Suprabha Suresh Nayak, Cannanore Ganesh Pai, Kapaettu Satyamoorthy |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male medicine.medical_specialty Cell Apoptosis INTESTINAL TUBERCULOSIS Inflammatory bowel disease Sensitivity and Specificity Flow cytometry Andrology Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Crohn Disease Predictive Value of Tests Internal medicine medicine Humans Lymphocyte Count Aged Crohn's disease medicine.diagnostic_test business.industry Gastroenterology Hepatology Middle Aged medicine.disease medicine.anatomical_structure Tuberculosis Gastrointestinal 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Differential diagnosis business |
| Zdroj: | Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 39(4) |
| ISSN: | 0975-0711 |
| Popis: | Intestinal tuberculosis (ITb) and Crohn’s disease (CD) mimic each other often leading to misdiagnosis. We evaluated the difference between ITb and CD using the extent of apoptosis in peripheral blood lymphocytes. CD4+ cells as a percentage of the lymphocytes and viable, dead, total apoptotic, early apoptotic, and late apoptotic CD4+ cells were assessed in the peripheral blood by flow cytometry in healthy controls and patients with confirmed active ITb and CD prior to initiating therapy. Early apoptotic and total apoptotic cells were further expressed as a proportion of the percentage of CD4+ cells. The percentages of CD4+ cells (6.5 [3.0, 8.7] vs. 13.40 [10.15, 13.40]; p |
| Databáze: | OpenAIRE |
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