Free Interleukin (IL)-18 Levels, and the Impact of IL18 and IL18BP Genetic Variation, in CHD Patients and Healthy Men
| Autor: | Carmel Stock, Menachem Rubinstein, Steve E. Humphries, Daniela Novick, Simon Thompson, Jackie A. Cooper, George J. Miller, Julie Sanders, DJ Brull, Patricia Woo |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Myocardial Infarction Coronary Disease Single-nucleotide polymorphism Polymorphism Single Nucleotide Gastroenterology Postoperative Complications Gene Frequency Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Prospective Studies Myocardial infarction Coronary Artery Bypass Prospective cohort study Aged business.industry Unstable angina Vascular disease Interleukin-18 Middle Aged medicine.disease Surgery Europe Phenotype Treatment Outcome medicine.anatomical_structure Haplotypes Case-Control Studies Intercellular Signaling Peptides and Proteins Interleukin 18 Cardiology and Cardiovascular Medicine business Follow-Up Studies IL18BP Artery |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 27:2743-2749 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvbaha.107.149245 |
| Popis: | Objective— To investigate free interleukin-18 (fIL-18) levels, and variation within the IL-18 system genes, in heart surgery patients, and healthy men. Methods and Results— fIL-18 was calculated from IL-18 and IL-18 binding protein (BP) levels, in 421 healthy men and 196 post–coronary artery bypass graft (CABG) patients. After surgery, fIL-18 peaked at 6 hours (from 117 to 331 pg/mL) but fell to below presurgery levels at 24 hours (99 pg/mL), because of changes in total IL-18 and IL-18BP. fIL-18 24 hours postsurgery was significantly higher in those who suffered a major complication after surgery (125 versus 80 pg/mL, P P =0.01). Tagging SNPs for IL18 (n=5) and IL18BP (n=3) were determined, in both studies the IL18 Hap III haplotype (frequency 30%) was associated with 36% lower baseline fIL-18 levels before surgery ( P P =0.04). The frequency of Hap III was lower in CABG patients than in healthy men (20.7 versus 29.8%, P Conclusions— IL-18 levels, which are determined in part by variation in IL18 , play a role in CHD development and postsurgery outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|