C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses
| Autor: | Lara M. Kingeter, Xin Lin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Transcriptional Activation
Immunology Syk Review Biology chemistry.chemical_compound C-type lectin Immunoreceptor tyrosine-based activation motif Animals Humans Syk Kinase Immunology and Allergy Lectins C-Type Inflammation Innate immune system Receptors IgG Intracellular Signaling Peptides and Proteins NF-kappa B Pattern recognition receptor Signal transducing adaptor protein NF-κB Protein-Tyrosine Kinases Immunity Innate Cell biology CARD Signaling Adaptor Proteins Infectious Diseases chemistry Receptors Pattern Recognition Signal transduction Signal Transduction |
| Zdroj: | Cellular & Molecular Immunology. 9:105-112 |
| ISSN: | 2042-0226 1672-7681 |
| DOI: | 10.1038/cmi.2011.58 |
| Popis: | The C-type lectin receptors (CLRs) belong to a large family of proteins that contain a carbohydrate recognition domain (CRD) and calcium binding sites on their extracellular domains. Recent studies indicate that many CLRs, such as Dectin-1, Dectin-2 and Mincle, function as pattern recognition receptors (PRRs) recognizing carbohydrate ligands from infected microorganisms. Upon ligand binding, these CLRs induce multiple signal transduction cascades through their own immunoreceptor tyrosine-based activation motifs (ITAMs) or interacting with ITAM-containing adaptor proteins such as FcRγ. Emerging evidence indicate that CLR-induced signaling cascades lead to the activation of nuclear factor kappaB (NF-κB) family of transcriptional factors through a Syk- and CARD9-dependent pathway(s). The activation of NF-κB plays a critical role in the induction of innate immune and inflammatory responses following microbial infection and tissue damages. In this review, we will summarize the recent progress on the signal transduction pathways induced by CLRs, and how these CLRs activate NF-κB and contribute to innate immune and inflammatory responses. |
| Databáze: | OpenAIRE |
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