Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients
| Autor: | Hiroshi Umadome, Soichiro Sakamoto, Hironori Haga, Junya Kanda, Chihiro Watanabe, Akifumi Takaori-Kondo, Nozomu Hanaoka, Mutsumi Okada, Naoyuki Anzai, Yoshiyuki Onda, Masaro Tashima, Tsuguto Fujimoto |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Adenoviridae Infections Autopsy Hematopoietic stem cell transplantation 030230 surgery 03 medical and health sciences 0302 clinical medicine allo-HSCT Cystitis Medicine Humans Disseminated disease Hepatitis Transplantation business.industry Adenoviruses Human Hematopoietic Stem Cell Transplantation virus diseases Common cold acute liver failure Liver Failure Acute medicine.disease eye diseases Epidemic Keratoconjunctivitis Pneumonia Infectious Diseases adenovirus hepatitis Immunology 030211 gastroenterology & hepatology business Encephalitis |
| Zdroj: | Transplant infectious disease : an official journal of the Transplantation SocietyREFERENCES. 23(2) |
| ISSN: | 1399-3062 |
| Popis: | Human adenovirus (HAdV) is an important cause of the common cold and epidemic keratoconjunctivitis in immunocompetent individuals. In immunocompromised patients, HAdV can sometimes cause severe infection such as cystitis, gastroenteritis, pneumonia, encephalitis, hepatitis, or disseminated disease, resulting in significant morbidity and also mortality. In particular, severe cases have been reported in patients after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Indeed HAdV has been recognized as a pathogen that requires careful monitoring in allo‐HSCT patients. While HAdV hepatitis leading to severe acute liver failure is rare, such liver failure progresses rapidly and is often fatal. Unfortunately, HAdV hepatitis has few characteristic symptoms and physical findings, which makes it difficult to promptly confirm and start treatment. We report here four cases of HAdV hepatitis after allo‐HSCT and their autopsy findings. |
| Databáze: | OpenAIRE |
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