The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck
| Autor: | K. A. McLay, G. Robertson, L. J. Clark, I. R. Swan, W. J. Newlands, Edington Kg, L. C. Wills, P. W. Johnston, H. A. Young, R. Mitchell |
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| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty viruses Cell Molecular Sequence Data Biology medicine.disease_cause Polymerase Chain Reaction White People law.invention Pathogenesis law medicine Tumor Cells Cultured Humans Base sequence Head and neck Polymerase chain reaction Mutation Base Sequence humanities stomatognathic diseases medicine.anatomical_structure Genes ras Oncology Head and Neck Neoplasms Carcinoma Squamous Cell Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five erythroplakias, 56 squamous cell carcinomas, and 16 SCC cell lines. Some of the SCC were lymph node metastases (three) or tumours which had recurred following radiotherapy (seven). We conclude that Harvey ras mutations are not a common event in the pathogenesis or recurrence of SCCs from Caucasian subjects, in contrast to the situation with Indian populations (Saranath et al., 1991). Images Figure 1 |
| Databáze: | OpenAIRE |
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