Iron Chelator or Iron Supplement Consumption in COVID-19? The Role of Iron with Severity Infection
| Autor: | Saba Fooladi, Sareh Zanganeh, Hamidreza Shiri, Alireza Bastin, Mohammad Hadi Nematollahi, Mohammad Amin Momeni Moghaddam, Mehrnaz Mehrabani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Endocrinology Diabetes and Metabolism medicine.medical_treatment Iron Clinical Biochemistry Iron supplement Disease Iron Chelating Agents Biochemistry Gastroenterology Article Inorganic Chemistry Hemoglobins Internal medicine medicine Humans Disease severity chemistry.chemical_classification Iron Chelator Ferritin biology Iron chelator business.industry Biochemistry (medical) Transferrin COVID-19 General Medicine Odds ratio Fe Trace Elements chemistry Case-Control Studies Ferritins biology.protein Hemoglobin business |
| Zdroj: | Biological Trace Element Research |
| ISSN: | 1559-0720 |
| Popis: | Iron is a trace element that is used to replicate the virus and has a role in the vital functions of the body and the host’s innate immune system. The mechanism of iron in COVID-19 severity is still not well understood. The aim of this study was to evaluate the association of the iron with COVID-19 severity. A case–control study was performed on 147 patients with a positive PCR test result and 39 normal individuals admitted to the Persian Gulf Martyrs Hospital in Bushehr, Iran. The iron profiles and related tests were measured along with hematological analytes. Hemoglobin (Hb), Fe, and saturated transferrin decreased in all the groups compared to the controls, but ferritin increased in the patient groups. After adjusting for age and sex, we found that increased ferritin levels augmented the odds ratio (OR) of the disease in the moderate (OR = 2.95, P = 0.007), severe (OR = 6.1, P 157.5 ng/dL, P 261.5 ng/dL, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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