Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing

Autor: Darren J. Kelly, Anthony G. Brooks, Pawel Kuklik, Melissa Neo, Dennis H. Lau, Shivshankar Thanigaimani, Han S. Lim, Prashanthan Sanders, Nicholas H. Chia, Yuan Zhang, David A. Saint, Lindsay Brown, Karen Drury, Nicholas J. Shipp, Hany Dimitri, Christopher X. Wong
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Aging
Anatomy and Physiology
Refractory Period
Electrophysiological
lcsh:Medicine
Arrhythmias
Cardiovascular
Rats
Inbred WKY
Muscle hypertrophy
Fibrosis
Risk Factors
Rats
Inbred SHR
Atrial Fibrillation
lcsh:Science
Multidisciplinary
Statistics
Atrial fibrillation
Animal Models
Electrophysiology
Hypertension
Cardiology
cardiovascular system
Medicine
Hypertrophy
Left Ventricular
medicine.symptom
Electrical conduction system of the heart
Research Article
medicine.medical_specialty
Clinical Research Design
In Vitro Techniques
Biostatistics
Spontaneously hypertensive rat
Model Organisms
Heart Conduction System
Internal medicine
medicine
Animals
Heart Atria
Animal Models of Disease
cardiovascular diseases
Biology
Fibrillation
Inflammation
business.industry
Myocardium
lcsh:R
Immunity
Atrial Remodeling
medicine.disease
Myocardial Contraction
Rats
Blood pressure
Endocrinology
Ageing
Rat
Clinical Immunology
lcsh:Q
business
Physiological Processes
Mathematics
Zdroj: PLoS ONE, Vol 8, Iss 8, p e72416 (2013)
PLoS ONE
ISSN: 1932-6203
Popis: Background: Both ageing and hypertension are known risk factors for atrial fibrillation (AF) although the pathophysiological contribution or interaction of the individual factors remains poorly understood. Here we aim to delineate the arrhythmogenic atrial substrate in mature spontaneously hypertensive rats (SHR). Methods: SHR were studied at 12 and 15 months of age (n=8 per group) together with equal numbers of age-matched normotensive Wistar-Kyoto control rats (WKY). Electrophysiologic study was performed on superfused isolated right and left atrial preparations using a custom built high-density multiple-electrode array to determine effective refractory periods (ERP), atrial conduction and atrial arrhythmia inducibility. Tissue specimens were harvested for structural analysis. Results: Compared to WKY controls, the SHR demonstrated: Higher systolic blood pressure (p
Databáze: OpenAIRE
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