Risk of thromboembolic events in atrial fibrillation with chronic kidney disease
| Autor: | Wu-Tao Zeng, Li-Juan Liu, Kai Tang, Wei-Yi Mei, Yun-Jiu Cheng, Qing Xu, Xiu-Ting Sun |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Renal function Severity of Illness Index Risk Factors Internal medicine Thromboembolism Atrial Fibrillation Medicine Humans In patient Renal Insufficiency Chronic Advanced and Specialized Nursing business.industry Atrial fibrillation medicine.disease Confidence interval Stroke Pooled analysis Relative risk Ischemic stroke Cardiology Neurology (clinical) Cardiology and Cardiovascular Medicine business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Stroke. 46(1) |
| ISSN: | 1524-4628 |
| Popis: | Background and Purpose— Chronic kidney disease may increase the risk for ischemic stroke or systemic embolism in patients with nonvalular atrial fibrillation (AF). We conducted a meta-analysis to summarize all published studies to investigate the link between chronic kidney disease and risk of thromboembolic events in AF. Methods— We performed a literature search using MEDLINE (source PubMed, 1966 to July, 2014) and EMBASE (1980 to July 2014) with no restrictions. Pooled effect estimates were obtained by using random-effects meta-analysis. Results— Eighteen studies involving 538 479 patients and 41 719 incident thromboembolic events were identified. From the pooled analysis, AF patients with estimated glomerular filtration rate P 2 slightly improved the stroke risk stratification. Conclusions— Impaired renal function is an independent predictor of stroke or systemic embolism in patients with nonvalvular AF. Consideration of renal function may improve stroke risk stratification in patients with AF. |
| Databáze: | OpenAIRE |
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