Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle
| Autor: | Stephen A. Stimpson, Lisa G. Clifton, Andrew N. Billin, Melissa Ducceschi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Muscle tissue
Male Histology Integrin beta Chains Physiology Skeletal muscle Biology Mice Muscular Diseases Transforming Growth Factor beta medicine Myocyte Regeneration Animals RNA Messenger RNA Processing Post-Transcriptional Muscle Skeletal Post-transcriptional regulation Regulation of gene expression Original Paper Integrin beta 6 Gene Expression Profiling Cell Biology General Medicine Transforming growth factor beta Molecular biology Immunohistochemistry medicine.anatomical_structure Gene Expression Regulation TGFbeta biology.protein Integrin beta 6 ITGA7 Repair Signal Transduction |
| Zdroj: | Journal of Molecular Histology |
| ISSN: | 1567-2387 1567-2379 |
| Popis: | We have identified integrin beta 6 (Itgb6) as a transcript highly enriched in skeletal muscle. This finding is unexpected because Itgb6 is typically associated with epithelial expression domains in normal tissue. Further we find that ITGB6 protein expression in muscle is post-transcriptionally regulated. Uninjured muscle expresses Itgb6 RNA but no ITGB6 protein is detectable. Muscle injury induces ITGB6 protein accumulation rapidly post-injury in myofibers adjacent to the site of injury. As regeneration of the injured muscle tissue progresses ITGB6 protein is found in newly formed fibers up to at least 15 days post-injury. |
| Databáze: | OpenAIRE |
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