The activity of erythrocyte enzymes and basic indices of peripheral blood erythrocytes from workers chronically exposed to mercury vapours
| Autor: | Zbigniew Zabiński, Zbigniew Dabrowski, Jan Rutowski, Paulin Moszczyński |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
0301 basic medicine
Adult Erythrocyte Indices Male medicine.medical_specialty Erythrocytes Iron Health Toxicology and Mutagenesis Glutathione reductase 010501 environmental sciences Glucosephosphate Dehydrogenase Toxicology 01 natural sciences 03 medical and health sciences Total iron-binding capacity Occupational Exposure Internal medicine medicine Humans Peripheral blood cell 0105 earth and related environmental sciences chemistry.chemical_classification 030102 biochemistry & molecular biology medicine.diagnostic_test biology Red Cell Superoxide Dismutase Transferrin Public Health Environmental and Occupational Health Mercury Middle Aged Enzymes Occupational Diseases Ferritin Glutathione Reductase Endocrinology Biochemistry chemistry Ferritins Mercury Poisoning Acetylcholinesterase Serum iron biology.protein Hemoglobin |
| Zdroj: | Toxicology and Industrial Health. 16:58-64 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1191/074823300678827663 |
| Popis: | The influence of occupational exposure to mercury vapours on the activity of the red cell enzymes [glucose-6-phosphate dehydrogenase (G-6PD), acetylcholinesterase (AChE), glutathione reductase (GR) and superoxide dismutase (SOD)], as well as on peripheral blood indices [erythrocyte number (RBC), HCT, Hb, MCHC] and on serum concentrations of iron, ferritin, transferrin and total iron binding capacity (TIBC), was assessed. Studies were carried out on 46 men aged between 21 and 56 years ( X=39±10.4) exposed to mercury vapours during their work from 7 months to 32 years (=14.7±10.8). The control group consisted of 35 healthy workers aged between 20 and 54 years ( X=33.6±9.8) not exposed to chemical nor physical agents. In both groups studied, there were 50% and 34.3% smokers, respectively. The activity of studied red cell enzymes—G-6PD, AChE, GR and SOD—was estimated according to the colorimetric methods described by Beutler and expressed as international units per gram of hemoglobin (IU g Hb−1). Peripheral blood cell parameters were determined using an automatic cell counter. The concentration of serum iron and TIBC was determined using colorimetric methods (Beckman), while that of ferritin and transferrin by nephelometric methods. The time-weighted average (TWA) of mercury concentration in the air determined before the study was 0.0028 mg m−3. Statistical analysis of the data was performed using either the Cochran and Cox C-test or the Student's t-test. The medium mercury concentration in the urine was 77.44±48.15 μg 1−1. In the group exposed to mercury vapours, a significant decrease was found in G-6PD activity (23.9%, P |
| Databáze: | OpenAIRE |
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