Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations in Patients with Schizophrenia: A Randomized Controlled, Cross-over Study
| Autor: | Seong-Uk Yeo, Tae-Young Hwang, Hong-Mei Jin, Inho Hwang, Jong-Il Park, Young-Chul Chung, Eun-Ji Kim, Yin Cui, Hyung Tae Kim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
business.industry Repetitive transcranial magnetic stimulation medicine.medical_treatment Auditory hallucinations Audiology medicine.disease Crossover study Transcranial magnetic stimulation Behavioral Neuroscience Psychiatry and Mental health Text mining nervous system Schizophrenia medicine Original Article Pharmacology (medical) In patient Psychiatry business Broca area |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| ISSN: | 2093-4327 1738-1088 |
| DOI: | 10.9758/cpn.2014.12.3.222 |
| Popis: | Objective A randomized double-blind cross-over trial was conducted in patients with persistent auditory hallucinations (AHs) to investigate whether bilateral repetitive transcranial magnetic stimulation (rTMS) at the temporoparietal area or Broca's area is more effective at high- or low-frequencies compared to a sham condition. Methods Twenty three patients with persistent AHs who remained stable on the same medication for 2 months were enrolled. They were randomized to one of four conditions: low-frequency (1 Hz)-rTMS to the temporoparietal area (L-TP), high-frequency (20 Hz)-rTMS to the temporoparietal area (H-TP), high-frequency (20 Hz)-rTMS to Broca's area (H-B), or sham. Results All the four rTMS conditions resulted in significant decrease in the scores under the auditory hallucination rating scale and hallucination change scale over time. However, there were no significant treatment effects or interaction between time and treatment, suggesting no superior effects of the new paradigms over the sham condition. Conclusion Our findings suggest that bilateral rTMS at the temporoparietal area or Broca's area with high- or low-frequency does not produce superior effects in reducing AHs compared to sham stimulation. |
| Databáze: | OpenAIRE |
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