A Case of Primary Synovial Sarcoma of the Thorax With a Variant SYT-SSX1 Fusion Transcript
| Autor: | Yoshiki Kohno, Shigeo Yasuda, Tatsuo Kato, Yoichiro Ueno, Toru Tanaka, Hiromasa Morikawa, Masatsugu Hamaji, Junya Toguchida |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Thorax Pathology medicine.medical_specialty Oncogene Proteins Fusion Risk Assessment Sarcoma Synovial Exon Primary Synovial Sarcoma Biopsy medicine Humans Neoplasm Staging medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction business.industry Biopsy Needle Genetic Variation Middle Aged Thoracic Neoplasms medicine.disease Immunohistochemistry Synovial sarcoma Reverse transcriptase Neoplasm Proteins Gene Expression Regulation Neoplastic Repressor Proteins Treatment Outcome Thoracotomy Fusion transcript Chemotherapy Adjuvant Radiotherapy Adjuvant Surgery Sarcoma Neoplasm Recurrence Local Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The Annals of Thoracic Surgery. 88:297-300 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/j.athoracsur.2008.12.054 |
| Popis: | With synovial sarcoma (SS) of the thorax, being exceptionally rare, its definite diagnosis is difficult, and the optimal therapy has not yet been established. An examination of our patient, a 64-year-old man with SS using a chest roentgenogram showed a large mass with homogeneous density in the lower two-thirds of the left hemithorax. A computed tomographic image of the chest revealed a large, heterogeneous, enhanced mass in the left hemithorax. Histologic examination of the resected tumor tissues suggested monophasic fibrous SS. A fragment of the SYT-SSX1 fusion transcript, which was smaller than the control, was amplified with reverse transcriptase polymerase chain reaction. Direct sequence analyses revealed the fusion between exon 9 of SYT and exon 5 of SSX1 instead of fusion between exon 10 of SYT and exon 6 of SSX1, which is found in most cases. Although the biological and clinical significance of this rare variant is not yet known, our data present another example of the usefulness of molecular analyses for making a definite diagnosis of SS in unusual sites. |
| Databáze: | OpenAIRE |
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