Pharmacokinetics of 99mTc-MAA- and 99mTc-HSA-Microspheres Used in Preradioembolization Dosimetry: Influence on the Liver–Lung Shunt
| Autor: | G Ulrich, Konrad Mohnike, Wolf Richter, Maciej Pech, Holger Amthauer, Philipp Genseke, Jens Ricke, Oliver S. Grosser, Annette Pethe, Dennis Kupitz, Juri Ruf |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Biodistribution medicine.medical_specialty Perfusion Imaging Serum albumin Technetium Tc 99m Aggregated Albumin Scintigraphy Gastroenterology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Internal medicine medicine Humans Tissue Distribution Radiology Nuclear Medicine and imaging Prospective Studies Lung Aged Aged 80 and over biology medicine.diagnostic_test Chemistry Liver Neoplasms Albumin Middle Aged Human serum albumin Embolization Therapeutic Microspheres Liver 030220 oncology & carcinogenesis biology.protein Female Colorectal Neoplasms Perfusion medicine.drug |
| Zdroj: | Journal of Nuclear Medicine. 57:925-927 |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.115.169987 |
| Popis: | Perfusion scintigraphy using 99mTc-labeled albumin aggregates is mandatory before hepatic radioembolization with 90Y-microspheres. As part of a prospective trial, the intrahepatic and intrapulmonary stability of 2 albumin compounds, 99mTc-MAA (macroaggregated serum albumin [MAA]) and 99mTc-HSA (human serum albumin [HSA]), was assessed. Methods: In 24 patients with metastatic colorectal cancer, biodistribution (liver, lung) and liver–lung shunt (LLS) of both tracers (12 patients each) were assessed by sequential planar scintigraphy (1, 5, and 24 h after injection). Results: Liver uptake of both albumin compounds decreased differently. Although initial LLSs at 1 h after injection were similar in both groups, MAA-LLS increased significantly from 1 (3.9%) to 5 h (7.7%) and 24 h (9.9%) after injection, respectively. HSA-LLS did not change significantly (1 to 5 h), indicating a steady state of pulmonary and intrahepatic degradation. Conclusion: Compared with 99mTc-MAA-microspheres, 99mTc-HSA-microspheres are likely more resistant to degradation over time, allowing a reliable LLS determination even at later time points. |
| Databáze: | OpenAIRE |
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