Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus
| Autor: | Bruno Moreira Carneiro, Mariana Nogueira Batista, Ricardo Barros Mariutti, Ana Claudia Silva Braga, Renata Prandini Adum de Matos, Cíntia Bittar, Maurício Lacerda Nogueira, Natalia Maria Candido, Marilia Freitas Calmon, Tairine Zara Lopes, Guilherme Campos, Paula Rahal, Raghuvir K. Arni, Marcos Michel Souza, Maria Letícia Duarte Lima, Stephane Tereza Queiroz de Andrade, Francielly Cristina Machado |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Mato Grosso Federal University |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Emodin Berberine 030106 microbiology lcsh:QR1-502 Virus Replication Antiviral Agents Article lcsh:Microbiology Virus Zika virus emodin 03 medical and health sciences chemistry.chemical_compound Virology Chlorocebus aethiops ZikV Infection Animals berberin Vero Cells Berberin ZIKV Medicine East Asian Traditional Infectivity Biological Products Plants Medicinal biology Chemistry Virion Zika Virus biology.organism_classification 030104 developmental biology Infectious Diseases Vero cell Medicinal herbs Vero E6 cells |
| Zdroj: | Viruses Volume 11 Issue 1 Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Viruses, Vol 11, Iss 1, p 49 (2019) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v11010049 |
| Popis: | Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µ M of berberine, a reduction of 77.6% in the infectivity was observed when emodin was used (40 µ M), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus. |
| Databáze: | OpenAIRE |
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