| Autor: |
Rebecca Garten, Yanbing Li, Nguyen Hong Diep, John Wood, Robert G. Webster, Le Quynh Mai, Nguyen Tien Dung, Hua Ian Chen, Alice Crosier, Masaji Mase, San Sorn, David E. Swayne, Haan Woo Sung, Maryse Tardy-Panit, Victoria Gregory, Saliha Azebi, Chun Kang, Masatsugu Obuchi, Jill Banks, Takehiko Saito, Frédérique Cuvelier, David L. Suarez, La Morris Loftin, Keiji Fukuda, Niranjan Bhat, Scott A. Harper, Erica Spackman, Rick A. Bright, Masaki Imai, Jean Thierry Aubin, Stéphanie Desvaux, James Robertson, Catherine K. Smith, Takato Odagiri, Jean Claude Manuguerra, Klaus Stöhr, Stephen Lindstom, Michael L. Perdue, Julia Desheva, Richard J. Webby, Wenging Zhang, Diane J. Hulse, Jan Mabry, Jean Marc Reynes, Marek J. Slomka, A. Hay, Sylvie van der Werf, Philippe Buchy, Doan Nguyen, Nancy J. Cox, Lindsay Edwards, Ai Ninomiya, Ian Brown, A. R. Douglas, Timothy M. Uyeki, Sirenda Vong, Phan Van Tu, Claudine Rousseaux, Shigeyuki Itamura, Jae Hong Kim, Malik Peiris, Margaret McCarron, Guohua Deng, Alexander Klimov, Elena A. Govorkova, Ruben O. Donis, Scott F. Dowell, Amanda Balish, Xiyan Xu, Yi Pu Lin, Samadhan Jadhao, Nguyen Thi Hong Hanh, Erich Hoffmann, Phuong Song Lien, Peter K.C. Cheng, Marie-Jo Medina, Patricia Jeannin, Masato Tashiro, Jackie Katz, Yumi Matsuoka, Aaron Curns, James Mark Simmerman, Pranee Thawatsupha, Somchai Sangkitporn, Ana Maria Burguiere, Alan W. Hampson, Guan Yi, Taronna R. Maines, Chang-Won Lee, Terrence M. Tumpey, Wilina Lim, Yong Kuk Kwon, Michael W. Shaw |
| Přispěvatelé: |
Institut Pasteur [Paris], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur d'Ho Chi Minh Ville, Research at St. Jude Hospital was supported in part by grant AI95357 from the National Institutes of Health., Institut Pasteur [Paris] (IP) |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Emerging Infectious Diseases
Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2005, 11 (10), pp.1515-1526. ⟨10.3201/eid1110.050644⟩
Emerging Infectious Diseases, 2005, 11 (10), pp.1515-1526. ⟨10.3201/eid1110.050644⟩ |
| ISSN: |
1080-6040
1080-6059 |
| DOI: |
10.3201/eid1110.050644⟩ |
| Popis: |
Human infections were from a virus clade undergoing antigenic drift that showed resistance to adamantanes but sensitivity to neuraminidase inhibitors.
An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused >52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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