Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-α secretion by macrophage-like cells
| Autor: | Mythily Srinivasan, L. V. Burton, E. E. Dobbins, Susan L. Zunt, Lawrence I. Goldblatt |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
DNA Bacterial Saliva Translational Studies medicine.medical_treatment Immunology Lipopolysaccharide Receptors Biology Polymerase Chain Reaction stomatognathic system medicine Humans Immunology and Allergy Macrophage RNA Messenger Receptor Analysis of Variance Toll-like receptor Tumor Necrosis Factor-alpha Macrophages Epithelial Cells medicine.disease Toll-Like Receptor 2 Toll-Like Receptor 4 stomatognathic diseases Cytokine Case-Control Studies Cytokine secretion Tumor necrosis factor alpha Oral lichen planus Lichen Planus Oral |
| Zdroj: | Clinical and Experimental Immunology. 156:285-293 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2009.03854.x |
| Popis: | Summary In health, mucosal inflammation is prevented by tightly regulated responses via Toll-like receptors (TLR) that interact with specific microbe associated molecular patterns. Currently, 13 TLRs have been identified. Based on the specificity of ligand recognition, TLR-2 and TLR-4 can recognize most oral commensal microorganisms. Recent identification of some soluble TLRs (sTLRs) suggests additional regulatory roles for these receptors. We report here the presence of sTLR-4 polypeptides in adult human saliva. Functionally, the salivary sTLR-4 suppressed cytokine secretion by activated macrophages. The sTLR-4 levels were elevated significantly in oral lichen planus (OLP), a chronic inflammatory condition of the oral mucosa characterized by clinical persistence. In contrast, the epithelial cells in the saliva of OLP subjects expressed significantly reduced TLR-2 and TLR-4 mRNA that correlated with fewer bacteria/salivary epithelial cells. Investigating the soluble and cellular components of saliva is useful in identifying potential biomarkers for oral mucosal lesions. |
| Databáze: | OpenAIRE |
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