Quantitative assessment of atrial conduit function: a new index of diastolic dysfunction
| Autor: | Rosaria Nappo, Anna Degiovanni, Paolo Cerini, Sándor J. Kovács, Gabriella Di Giovine, Rita Fossaceca, Paolo Marino, Chiara Sartori, Virginia Bolzani |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Echocardiography Three-Dimensional Diastole 030204 cardiovascular system & hematology Doppler echocardiography Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Electrical conduit Left atrial Internal medicine Severity of illness medicine Quantitative assessment Humans cardiovascular diseases 030212 general & internal medicine Aged Heart Failure Original Paper medicine.diagnostic_test business.industry Stroke Volume General Medicine Stroke volume Middle Aged medicine.disease Echocardiography Doppler Left atrial conduit function Heart failure cardiovascular system Cardiology Diastolic dysfunction Atrial Function Left Female Full-volume 3D-echocardiography Cardiology and Cardiovascular Medicine business |
| Zdroj: | Clinical Research in Cardiology |
| ISSN: | 1861-0692 1861-0684 |
| Popis: | Background Heart failure (HF) epidemic has increased need for accurate diastolic dysfunction (DD) quantitation. Cardiac MRI can elucidate left atrial (LA) phasic function, and accurately quantify its conduit contribution to left ventricular (LV) filling, but has limited availability. We hypothesized that the percentage of LV stroke volume due to atrial conduit volume (LACV), as assessed using 3D-echocardiography, can differentiate among progressive degrees of DD in HF patients. Methods and results Sixty-three subjects (66 ± 12 years) with DD and ejection fraction (EF) ranging 14–62 % underwent full-volume 3D-echocardiography. Simultaneous LA and LV volume curves as function of time (t) were calculated, with LACV as \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{LACV}}\left( t \right) \, = \, \left[ {{\text{LV}}\left( t \right){-}{\text{LV minimum}}} \right] \, - \, \left[ {{\text{LA maximum }} - {\text{ LA}}\left( t \right)} \right]$$\end{document}LACVt=LVt-LV minimum-LA maximum-LAt, expressed as % of stroke volume. Patients were assigned to four (0–3, from none to severe) DD grades, according to classical Doppler parameters. In this population DD is linked to LACV, with progressively higher percentages of conduit contribution to stroke volume associated with higher degrees of DD (p = 0.0007). Patients were then dichotomized into no-mild (n = 26) or severe (n = 37) DD groups. Apart from atrial volume, larger (p |
| Databáze: | OpenAIRE |
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