Reinfection of virus free mice with mouse mammary tumour virus
| Autor: | L. A. Rogers, A. E. Lee, S. Topps, K. Wallace |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Aging
animal structures viruses Weanling Mammary tumour Tumour incidence Virus Cohort Studies Mice Pregnancy Medicine Animals Pregnancy Complications Infectious Virus free Maternal-Fetal Exchange Mice Inbred ICR General Veterinary business.industry Mammary Neoplasms Experimental Virology Animals Suckling Specific Pathogen-Free Organisms Mice Inbred C57BL Milk Mammary Tumor Virus Mouse Immunology Animal Science and Zoology Female Disease Susceptibility business |
| Zdroj: | Laboratory animals. 23(2) |
| ISSN: | 0023-6772 |
| Popis: | BR6/Icrf mice carrying a milk-transmitted mammary tumour virus (MMTV) develop tumours after several pregnancies. If the mice are freed from MMTV, no tumours develop. In the experiments described in this paper, MMTV was reintroduced into MMTV-free mice by foster nursing, which was least effective if the pups were exposed to the virus only during the first week of life. Exposure for even a short time after that age led to a tumour incidence similar to that found in normally infected mice. Reinfection was also achieved by injection of MMTV-containing milk into weanling or pregnant mice, and was then transmitted naturally to the next generation. |
| Databáze: | OpenAIRE |
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