Malignant lymphoma localized in the abdomen: detection of Ig gene rearrangement from the specimen obtained by percutaneous lymph node biopsy
| Autor: | Masaya Wakabayashi, Takao Iiri, Satoshi Ito, Naoki Hayashi, Takaaki Chou, Kazuyuki Kurasige, Masaaki Arakawa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lymphoma B-Cell Lymph node biopsy Diagnosis Differential Biopsy Internal Medicine medicine Gene Rearrangement B-Lymphocyte Light Chain Humans medicine.diagnostic_test business.industry Biopsy Needle General Medicine medicine.disease Leukemia Lymphocytic Chronic B-Cell Abdominal mass Lymphoproliferative Disorders Lymphoma Non-Hodgkin's lymphoma medicine.anatomical_structure Abdominal ultrasonography Abdominal Neoplasms Abdomen medicine.symptom business Superficial Lymph Node |
| Zdroj: | Internal medicine (Tokyo, Japan). 31(11) |
| ISSN: | 0918-2918 |
| Popis: | A 32-year-old man was admitted to our hospital because of lumbago and an abdominal mass revealed by abdominal ultrasonography. Abdominal CT scan and MRI revealed multiple para-aortic lymph node swelling involving several arteries and veins. As there was no superficial lymph node swelling, percutaneous lymph node biopsy was performed under ultrasonographic guide. Although non-Hodgkin's lymphoma, diffuse, small cell type was suspected by light microscopic study, the monoclonality of the lymphocytes in the obtained specimen was not clear by the immunohistochemical study. Southern blot hybridization analysis of the biopsy specimen revealed the rearrangement of IgH and IgL (λ) chain gene, indicating the existence of monoclonal proliferation of lymphoma cells. The DNA analysis appears useful for the differential diagnosis of lympho-proliferative diseases.(Internal Medicine 31 : 1281-1285, 1992) |
| Databáze: | OpenAIRE |
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