Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships

Autor:	Iraj Lalezari, Parviz Lalezari
Rok vydání:	1989
Předmět:	Erythrocytes Molecular Structure Chemistry Stereochemistry chemistry.chemical_element 2-Methylpropionic Acids In Vitro Techniques Oxygen Phenoxyacetates Glycolates Hemoglobins Structure-Activity Relationship Oxyhemoglobins Drug Discovery Molecular Medicine Humans Hemoglobin Propionates
Zdroj:	Journal of medicinal chemistry. 32(10)
ISSN:	0022-2623
Popis:	A series of 2-[4-[[[(substituted-phenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acids and other substituted phenoxyacetic acids were synthesized and tested for their ability to reduce the affinity of hemoglobin for oxygen. 2-[4-[[[(3,4,5-trichlorophenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acid was found to be the most potent compound known. Structure-activity relationships of the compounds synthesized are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf5c6902968f9fff66844b3ad043751 https://pubmed.ncbi.nlm.nih.gov/2795607 Zobrazit plný text záznamu